Study of synthesis parameters on the physical properties and morphology of smart PNIPAAm hydrogels

Abstract Bone loss is common in human old age and new materials that promote bone regeneration are an active line of research. In the present work, seven smart hydrogels based on PNIPAAm were synthesized with prospective to be used tissue engineering as a scaffold for growth. By changing stoichiometric concentrations reagents synthesis parameters, different physical properties morphology obtained. Swelling, degradation properties, crystallinity analyzed. Physical characterized using 1 H-NMR, FTIR, TGA. The results showed swelling degree (degree mass expansion) varied at room temperature from 1,400% less rigid 550% stiffer hydrogels. With heating body temperature, decreases 300% 200%, respectively. samples presented three-dimensional morphology, but they acquired structures according magnetic stirring during process. crosslink initiator have important effect polymeric structure thermal stability 8.9 15.7 mol % MBA most promising compounds future biomedical applications due their high stability, satisfactory 3D surface shrinking-swelling property.